WEBVTT 00:00:03.265 --> 00:00:07.265 We were able to get these Niemann-Pick patient cell lines from Coriell. 00:00:07.265 --> 00:00:10.545 And so these cells are actually really useful because they allowed us to 00:00:10.545 --> 00:00:13.825 really understand what Ebola needs, in terms of NPC1. 00:00:13.825 --> 00:00:18.205 We're really using the virus as a tool to teach us about exactly how NPC1 00:00:18.205 --> 00:00:22.265 moves around in the cell in order to do its job, for example, what the structure 00:00:22.265 --> 00:00:24.295 of NPC1 looks like as a molecule. 00:00:24.875 --> 00:00:27.855 Having the structure of it would allow you to develop better drugs 00:00:27.855 --> 00:00:29.305 to preserve its function. 00:00:29.305 --> 00:00:31.325 We're doing this from this virus-centric view, 00:00:31.325 --> 00:00:34.095 but I think that this general knowledge that we would learn about NPC1 00:00:34.095 --> 00:00:39.155 and how it works, by really using the virus could provide information 00:00:39.155 --> 00:00:42.445 that would be useful for other scientists that are trying to develop therapies 00:00:42.445 --> 00:00:44.135 to treat Niemann-Pick disease. 00:00:44.343 --> 00:00:48.343 And so in fact we have a collaboration with a scientist at Mount Sinai, 00:00:48.343 --> 00:00:51.483 Yiannis Ioannou, who works on NPC1 and Niemann-Pick disease, 00:00:51.483 --> 00:00:53.903 where they're looking for drugs to make NPC1 better. 00:00:54.450 --> 00:00:58.303 But in the process of finding those drugs, they also found drugs that make it worse. 00:00:58.503 --> 00:01:01.283 And so we're taking those off his hands and using them for Ebola. 00:01:01.617 --> 00:01:04.117 And so if we go looking for drugs that make NPC1 worse, 00:01:04.117 --> 00:01:07.237 we may also find ones that make it better, and we can give them to other people. 00:01:07.237 --> 00:01:10.657 We're hoping that the work we do will benefit, you know, 00:01:10.657 --> 00:01:13.597 the work that's going on to treat Niemann-Pick disease, 00:01:13.597 --> 00:01:16.876 in just the way that the work that's being done to treat Niemann-Pick disease 00:01:16.876 --> 00:01:18.746 has already benefited the work that we're doing.